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Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats
(Sociedade Brasileira de Pesquisa Odontológica (SBPqO), 2011-01-01)
Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) ...
Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
(Colegio Farmaceuticos Provincia de Buenos Aires, 2010-12-01)
Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; ...
Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats
(Wiley-Blackwell Publishing, Inc, 2009-08-01)
Background and Objective:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether ...
The influence of local administration of simvastatin in calvarial bone healing in rats
(Churchill Livingstone, 2011-04-01)
Some authors have associated the use of statins, hypolipidemic drugs, and new bone formation. The aim of this work was to evaluate the effect of locally administered simvastatin on bone healing. Bone calvarial defects 5 ...
Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
(2006-12-01)
The purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia ...
Improved endothelial function with simvastatin but unchanged insulin sensitivity with simvastatin or ezetimibe
(Elsevier B.V., 2010-06-01)
In addition to their expected effects on lipid profile, lipid-lowering agents may reduce cardiovascular events because of effects on nonclassic risk factors such as insulin resistance and inflammation. Ezetimibe specifically ...
Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.
(2002-12-01)
The purpose of this study was to evaluate the effects of simvastatin on guided bone regeneration in the mandibles of ovariectomized rats, and to observe their blood cholesterol levels. Seventy female rats were divided into ...
Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study
(Biomed Central Ltd., 2009-01-07)
Background: Much attention has been drawn to different alternative strategies for cardiovascular disease prevention. Objective: The aim of the present study was to observe and compare the effects of Enterococcus faecium ...
The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats
(2007-12-01)
Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have ...
The effect of simvastatin treatment on bone repair of femoral fracture in animal model
(Informa Healthcare, 2015)