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Acute renal ischemia model in dogs: Effects of metoprolol
(Marcel Dekker Inc, 2001-01-01)
Introduction: To study the functional and hystological alterations in dog kidneys submitted to total ischemia for thirty minutes and the possible metoprolol protective action. Material and methods: Sixteen dogs anesthetized ...
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho
(Elsevier, 2017)
Abstract: Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium ion entry through the ...
Compensatory renal growth protects mice against Shiga toxin 2-induced toxicity
(Springer Verlag Berlín, 2006-05)
Uninephrectomy (Unx) is followed by the compensatory renal growth (CRG) of the remaining kidney. Previous evidence has shown that during CRG, renal tissue is resistant to a variety of pathologies. We tested the hypothesis ...
Sulfur‐containing amino acids that increase renal glutathione protect the kidney against papillary necrosis induced by 2‐bromoethylamine
(1990)
Papillary necrosis was observed in the kidneys of rats, 72 h after receiving a single injection of bromoethylamine (BEA). This effect was associated with renal glutathione (GSH) depletion 1 h after the administration of ...
Pharmacological treatment with galectin-1 protects against renal ischaemia-reperfusion injury
(2018-12-01)
Galectin-1 protein (GAL-1) has important anti-inflammatory properties, but related pharmacologic approaches to effectively treat or prevent renal ischaemia and reperfusion injury are highly limited. Here, we investigated ...
Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats
(Springer Basel Ag, 2012-03-01)
Cyclosporine (CsA) remains an important immunosuppressant for transplantation and for treatment of autoimmune diseases. The most troublesome side effect of CsA is renal injury. Acute CsA-induced nephrotoxicity is characterized ...
Microalbuminúria: fator de risco cardiovascular e renal subestimado na prática clínica
(Sociedade Brasileira de Endocrinologia e Metabologia, 2006-04-01)
Determination of microalbuminuria has been shown to be useful to identify patients with type 2 diabetes (DM2) at high risk of renal and cardiovascular (CV) diseases. The determination of the albumin/ creatinine (Cr) ratio ...
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho
(Nature Publishing Group, 2017-04)
Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium ion entry through the TRPC6 channel ...
Cyclic adenosine monophosphate protects renal cell lines against amphotericin B toxicity in a PKA-independent manner
(Taylor & Francis Ltd, 2016-01-02)
Amphotericin B is the gold standard agent in the management of serious systemic fungal infections. However, this drug can cause nephrotoxicity, which contributes up to 25% of all acute kidney injuries in critically ill ...