Buscar
Mostrando ítems 1-10 de 35
Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo [1,2-c]quinazolines
(2006)
The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments ...
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
(SOC BIOLGIA CHILE, 2008)
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
Synthesis, 2D-QSAR studies and biological evaluation of quinazoline derivatives as potent anti-trypanosoma cruzi agents
(Bentham Science Publishers, 2018-10)
Background: Chagas disease affects about 7 million people worldwide. Only two drugs are currently available for the treatment for this parasite disease, namely, benznidazol (Bzn) and nifurtimox (Nfx). Both drugs have limited ...
Effects of an antimalarial quinazoline derivative on human erythrocytes and on cell membrane molecular models
(ELSEVIER SCIENCE BV, 2012)
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: Discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
In this work we reported the synthesis and evaluation of the analgesic, anti-inflammatory, and platelet anti-aggregating properties of new 3-(arylideneamino)-2-methyl-6,7-methylenedioxy-quinazolin-4 (3H)-one derivatives ...
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
(Sociedad de Biología de Chile, 2008)
Solvent-free synthesis of 6-arylbenzimidazo[1,2-c]quinazolines under microwave irradiation
(GEORG THIEME VERLAG KG, 2004-02-18)
The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives 5-9 and their reduction to the corresponding 2-benzimidazoylbenzamides 10-13 are described. Compounds 10-13 were cleanly and efficiently converted ...
Access to quinazolines from 2-nitrobenzaldehyde and arylamines
(1999)
A synthesis of N-(2-nitrobenzyl)acetanilide (5) and (11) from 2- nitrobenzaldehyde and aromatic amines is reported. The reaction of amides (5) and (11) with iron in acetic acid-ethanol-water provided the corresponding 3- ...
Deleterious effects of VEGFR2 and RET inhibition in a preclinical model of Parkinson’s disease
(Humana Press Inc., 2018)