Artículos de revistas
Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo [1,2-c]quinazolines
Fecha
2006Registro en:
Journal of the Chilean Chemical Society, Volumen 51, Issue 2, 2018, Pages 927-932
07179324
07179324
Autor
Insuasty, B. A.
Torres, H.
Quiroga, J.
Abonía, R.
Rodríguez, R.
Nogeras, M.
Sánchez, A.
Saitz, C.
Alvarez, S. L.
Zacchino, S. A.
Institución
Resumen
The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as 1H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibited mainly T. rubrum and E. floccosum with MICs between 25-250 μg/mL and M. canis, M. gypseum and T. mentagrophytes with MICs between 50-250 μg/mL. Structures with electron-withdrawing substituents on the phenyl ring did not show any activities up to 250 μg/ml. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series. © 2006 Sociedad Chilena de Química.