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Chloroplast protein degradation in senescing leaves: Proteases and lytic compartments
(Frontiers Media, 2019-06-19)
Leaf senescence is characterized by massive degradation of chloroplast proteins, yet the protease(s) involved is(are) not completely known. Increased expression and/or activities of serine, cysteine, aspartic, and ...
Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation
(Public Library of Science, 2010-12)
Phosphorylation-triggered degradation is a common strategy for elimination of regulatory proteins in many important cell signaling processes. Interesting examples include cyclin-dependent kinase inhibitors such as p27 in ...
Oomycete intracellular effectors: Specialized weapons targeting strategic plant processes
(Wiley Blackwell Publishing, Inc, 2021-10-27)
Oomycete phytopathogens have adapted to colonise plants using effectors as their molecular weapons. Intracellular effectors, mostly proteins but also small ribonucleic acids, are delivered by the pathogens into the host ...
BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade
(Nature Publishing Group, 2021-12)
Bromodomain and Extra-Terminal domain (BET) family proteins are epigenetic readers thatplay a critical role in oncogenesis by controlling the expression of oncogenes such as c-Myc.Targeting BET family proteins has recently ...
Bacterial S-Layer Proteins for Stabilization of Food Ingredients Encapsulated in Liposomes
(Humana Press, 2021)
To protect food ingredients from degradation that can occur in the harsh environmental conditions of the gastrointestinal tract, many different oral delivery systems such as liposomes have been developed. However, liposomes ...
Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase
(Nature Publishing Group, 2017-06)
Upon different types of stress, the gene encoding the mitosis-promoting phosphatase Cdc25C is transcriptionally repressed by p53, contributing to p53’s enforcement of a G2 cell cycle arrest. In addition, Cdc25C protein ...
Quantitative proteomic and transcriptional analyses reveal degradation pathway of γ- hexachlorocyclohexane and the metabolic context in the actinobacterium Streptomyces sp. M7
(Pergamon-Elsevier Science Ltd, 2018-07)
Highly γ-hexachlorocyclohexane (lindane) contaminated areaswere reported worldwide. Low aqueous solubility and high hydrophobicitymake lindane particularly resistant to microbial degradation.Physiological and genetic ...