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Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes
(Company of Biologists, 2018-06)
Alzheimer disease (AD) pathology includes the accumulation of poly-ubiquitylated (also known as poly-ubiquitinated) proteins and failures in proteasome-dependent degradation. Whereas the distribution of proteasomes and its ...
20S proteasome and accumulation of oxidized and ubiquitinated proteins in maize leaves subjected to cadmium stress
(Pergamon-Elsevier Science Ltd, 2007-04)
In order to examine the possible involvement of the 20S proteasome in degradation of oxidized proteins, the effect of different cadmium concentrations on its activities, protein abundance and oxidation level were studied ...
The activity of the 20S proteasome is maintained in detached wheat leaves during senescence in darkness
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2002-02)
In the present paper, we studied the participation of the 20S proteasome, the proteolytic component of the ubiquitin-proteasome pathway, in the remobilization of bulk proteins in senescing wheat leaves. The detached leaves ...
Tyrosine hydroxylase is short-term regulated by the ubiquitin-proteasome system in PC12 cells and hypothalamic and brainstem neurons from spontaneously hypertensive rats: Possible implications in hypertension
(Public Library of Science, 2015-02)
Aberrations in the ubiquitin-proteasome system (UPS) are implicated in the pathogenesis of various diseases. Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamines biosynthesis, is involved in hypertension ...
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors
(Elsevier, 2016-08)
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of ...
Evidencing a pancreatic ductal adenocarcinoma subpopulation sensitive to the proteasome inhibitor Carfilzomib
(American Association for Cancer Research, 2020-10)
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate less than 5%. Multiple chemotherapeutic drugs have been tested to improve patient prognosis; however, the clinical efficacy of these ...