Buscar
Mostrando ítems 1-10 de 46
TGFβ1 regulates prolactin secretion during postnatal development: Gender differences
(BioScientifica, 2020-07)
Serum prolactin levels gradually increase from birth to puberty in both male and female rats, with higher levels observed in female since the first days of life. The increase in lactotroph secretion was attributed to the ...
TGFβ1 regulates prolactin secretion during postnatal development: gender differences
(BioScientifica, 2020-07)
Serum prolactin levels gradually increase from birth to puberty in both male and female rats, with higher levels observed in female since the first days of life. The increase in lactotroph secretion was attributed to the ...
Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression
(American Physiological Society, 2012-01)
Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed that prolactin inhibits its ...
Pituitary changes involved in prolactin secretion induced by mifepristone and naloxone during late pregnancy
(Karger, 2009-10)
The antiprogesterone mifepristone facilitates prolactin release, an effect enhanced by administration of the opioid antagonist naloxone. The present study explores ultrastructural changes in lactotropes after mifepristone ...
Lipopolysaccharide- and tumor necrosis factor-alpha-induced changes in prolactin secretion and dopaminergic activity in the hypothalamic-pituitary axis
(Karger, 2002-01)
Bacterial lipopolysaccharide (LPS) affects pituitary hormone secretion, including prolactin release, by inducing synthesis and release of cytokines such as tumor necrosis factor-α(TNF-α). Since prolactin is mainly under ...
Interaction between substance P and TRH in the control of prolactin release
(BioScientifica, 2000-02)
Substance P (SP) may participate as a paracrine and/or autocrine factor in the regulation of anterior pituitary function. This project studied the effect of TRH on SP content and release from anterior pituitary and the ...
New insights into progesterone actions on prolactin secretion and prolactinoma development
(Elsevier Science Inc., 2019-09-12)
Progesterone (P4) has controversial physiological effects on the regulation of the lactotroph population. While some studies have shown a negative role for P4 in prolactin secretion and lactotroph proliferation, antagonizing ...
Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer
(Impact Journals, 2020-12)
Progesterone receptor (PR) isoforms can drive unique phenotypes in luminal breast cancer (BC). Here, we hypothesized that PR-B and PR-A isoforms differentially modify the cross-talk between prolactin and fatty acid synthase ...
Nitric oxide mediates the inhibitory effect of tumor necrosis factor-α on prolactin release
(Karger, 2001-12)
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that markedly affects neuroendocrine functions. This cytokine is expressed in the anterior pituitary where its receptors are also present. Nitric oxide (NO) is ...
Desensitization of Angiotensin II effect on [Ca2+]i, inositol triphosphate and prolactin in pituitary cells
(American Physiological Society, 2001-12)
Activation of pituitary angiotensin (ANG II) type 1 receptors (AT1) mobilizes intracellular Ca2+, resulting in increased prolactin secretion. We first assessed desensitization of AT1 receptors by testing ANG II-induced ...