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T Cell Epitope Predictions
(Annual Reviews, 2020-04)
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes ...
In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine
(Elsevier, 2018-04)
Background: Chlamydia trachomatis is the most common sexually transmitted bacterial infection globally. Currently, there are no vaccines available despite the efforts made to develop a protective one. Polymorphic membrane ...
Development of bióinformatics tools to analyse peptide-protein interactións: immunoinformatics applicatións in next generatión vaccine design
(2017)
Epitope-based vaccines (EVs) make use of short, antigen-derived peptides corresponding
to epitopes that are administered lo trigger a protective humoral (B-cell epitopes) and/or
cellular (T-cell epitopes) immune response. ...
Automatic Generation of Validated Specific Epitope Sets
(Hindawi, 2015)
Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and ...
Bioinformatics tools for the prediction of T-cell epitopes
(Springer, 2018-05)
T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore ...
Identification and evaluation in-vitro of conserved peptides with high affinity to MHC-I as potential protective epitopes for Newcastle disease virus vaccines
(BioMed Central, 2023)
Background: Newcastle disease (ND) is a major threat to the poultry industry, leading to significant economic losses. The current ND vaccines, usually based on active or attenuated strains, are only partially effective and ...
Immunoinformatic identifcation of B cell and T cell epitopes in the SARS‐CoV‐2 proteome
A novel coronavirus (SARS-CoV-2) emerged from China in late 2019 and rapidly spread across the
globe, infecting millions of people and generating societal disruption on a level not seen since the
1918 infuenza pandemic. ...
Computer-aided design of T-cell epitope-based vaccines : Addressing population coverage
(2015-10-01)
Epitope-based vaccines (EVs) make use of short antigen-derived peptides corresponding to immune epitopes, which are administered to trigger a protective humoral and/or cellular immune response. EVs potentially allow for ...
Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design
(Frontiers in Bioscience, 2021-02-19)
Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models ...