info:eu-repo/semantics/article
Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design
Fecha
2021-02-19Registro en:
Hare, Jonathan; Morrison, David; Nielsen, Morten; Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design; Frontiers in Bioscience; Frontiers in Bioinformatics; 1; 622992; 19-2-2021; 1-5
2673-7647
CONICET Digital
CONICET
Autor
Hare, Jonathan
Morrison, David
Nielsen, Morten
Resumen
Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models to assess the sequence diversity of circulating SARS-CoV-2 proteomes in the context of an individual?s CD8 T-cell immune repertoire to identify potential. defined regions of immunogenicity. Using this approach of expedited and rational CD8 T-cell vaccine design, it may be possible to develop a therapeutic vaccine candidate with the potential for both global and local coverage.