info:eu-repo/semantics/article
T Cell Epitope Predictions
Fecha
2020-04Registro en:
Peters, Bjoern; Nielsen, Morten; Sette, Alessandro; T Cell Epitope Predictions; Annual Reviews; Annual Review Of Immunology; 38; 4-2020; 123-145
0732-0582
CONICET Digital
CONICET
Autor
Peters, Bjoern
Nielsen, Morten
Sette, Alessandro
Resumen
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity, transplantation, and cancer. The specific T cell epitopes recognized in an individual are determined by genetic factors such as the MHC molecules the individual expresses, in parallel to the individual's environmental exposure history. The complexity and importance of T cell epitope mapping have motivated the development of computational approaches that predict what T cell epitopes are likely to be recognized in a given individual or in a broader population. Such predictions guide experimental epitope mapping studies and enable computational analysis of the immunogenic potential of a given protein sequence region.