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Role of proteases in dysfunctional placental vascular remodelling in preeclampsia
(2020-02-01)
Preeclampsia is a syndrome characterised by vascular dysfunction, impaired angiogenesis, and hypertension during pregnancy. Even when the precise pathophysiology of preeclampsia remains elusive, impaired vascular remodelling ...
Autophagy Process in Trophoblast Cells Invasion and Differentiation : Similitude and Differences With Cancer Cells
(2021-04-15)
Early human placental development begins with blastocyst implantation, then the trophoblast differentiates and originates the cells required for a proper fetal nutrition and placental implantation. Among them, extravillous ...
Gestational diabetes mellitus treatment schemes modify maternal plasma cholesterol levels dependent to women´s weight : Possible impact on feto-placental vascular function
(2020-02)
Gestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes ...
Maternal supraphysiological hypercolesterolemia leads to endothelial dysfunction of the human fetoplacental macro and microvasculature
(2015)
Maternal physiological hypercholesterolemia (MPH) occurs in pregnancy assuring fetal growth and development. However, maternal supraphysiological hypercholesterolemia (MSPH) leads to increased atherosclerosis in the fetal ...
Spatio-temporal expression of MMP-2, MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig (Cavia porcellus)
(2007)
Abstract
Background
In humans trophoblast invasion and vascular remodeling are critical to determine the fate of pregnancy. Since guinea-pigs share with women an extensive ...
Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy
(2016-05-01)
Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic disruptions leading to alterations of the mother, ...