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Review of pharmacological options for the treatment of Chagas disease
(Wiley Blackwell Publishing, Inc, 2020-12-13)
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both rural and urban areas. CD was first described over a century ago, but only two drugs are currently available for CD treatment: ...
A novel hybrid promoter responsive to pathophysiological and pharmacological regulation
(Springer, 2012-04)
The aim of this study was to construct a promoter containing DNA motifs for an endogenous transcription factor associated with inflammation along with motifs for pharmacological regulation factors. We demonstrate in ...
Role of GABAB receptors on morphine antinociception in male and female mice: Pharmacological and genetic approaches
(Pergamon-Elsevier Science Ltd, 2019-03)
Previous studies in our laboratory showed an interaction between the GABAergic and opioid systems involved in the analgesic effect of baclofen (BAC). Furthermore, it is known that sex differences exist regarding various ...
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: Genetic and pharmacological approaches
(Elsevier, 2014-01)
Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the ...
Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
(Elsevier, 2019-12-29)
Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the ...
Differential response of pineal microglia to surgical versus pharmacological stimuli
(Wiley-liss, Div John Wiley & Sons Inc, 2018-10)
Microglial cells are one of the interstitial elements of the pineal gland (PG). We recently reported the pattern of microglia colonization and activation, and microglia-Pax6+ cell interactions during normal pineal ontogeny. ...
Pharmacological and genetical evidence supporting nitric oxide requirement for 2,4-epibrassinolide regulation of root architecture in Arabidopsis thaliana
(Taylor & Francis, 2013-07)
Brassinosteroids (BRs) regulate various physiological processes, such as tolerance to stresses and root growth. Recently, a connection was reported between BRs and nitric oxide (NO ) in plant responses to abiotic stress. ...
Don't just say no: Differential pathways and pharmacological responses to diverse nitric oxide donors
(Pergamon-Elsevier Science Ltd, 2018-10)
Nitric oxide (NO[rad]) is a gaseous free radical molecule with a short half-life (∼1 s), which can gain or lose an electron into three interchangeable redox-dependent forms, the radical (NO[rad]), the nitrosonium cation ...
Long-term effects of early life stress exposure: role of epigenetic mechanisms
(Elsevier, 2016-07)
Stress is an adaptive response to demands of the environment and thus essential for survival. Exposure to stress during the first years of life has been shown to have profound effects on the growth and development of an ...
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma
(Elsevier, 2020-06)
Purpose: Chronic and persistent exposure to negative stress can lead to adverse consequences on health. Particularly, psychosocial factors were found to increase the risk and outcome of respiratory diseases like asthma. ...