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A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits
(2006-09-01)
Pharmacokinetics of antivenoms has been mainly studied in normal animals, whereas very little is known on pharmacokinetics in envenomed animals. The aim of this study was to compare pharmacokinetic parameters of whole IgG ...
Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration
(Sociedad de Biología de Chile, 2009)
Pharmacokinetic considerations in critically ill patients Consideraciones farmacocinéticas en el paciente crítico
(2012)
Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Wiley-Blackwell, 2007-11-01)
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property
(Wiley-Blackwell, 2012-11-01)
Primaquine is an important therapeutic resource for malaria treatment and it has wide activity against several pathogens. The haematotoxicity of primaquine is the major problem for its therapeutic application. This effect ...
Pharmacokinetic study of long-acting oxytetracycline in cows. Estudio cinético de oxitetraciclina de larga acción en bovinos de Iechería
(1996)
Pharmacokinetics of a long-acting formula of oxytetracycline (OTC) in one formulation of dymetylacetomide, was studied in seven-cows after i.m. administration (20 mg/kg of body weight). Serum OTC concentration was measured ...
Pharmacokinetics and Biodistribution of Eriocitrin in Rats
(2021-02-17)
Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites ...
Pharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesia
(Soc Brasileira Quimica, 2010-01-01)
The aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received ...