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Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers
(Informa Healthcare, 2014-04)
Introduction: β-blocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all β-blockers shared their ability to competitively ...
Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C
(Taylor & Francis, 2018-06)
Introduction: Many reports have evaluated the clinical efficacy and safety of the fixed-dose all-oral combination of daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO), which was approved in Japan in December 2016 for the ...
Applicability of microdialysis as a technique for pharmacokinetic- pharmacodynamic (PK-PD) modeling of antihypertensive beta-blockers
(Elsevier, 2005-09)
Introduction: The aim of the present work was to examine microdialysis as a technique for the study of pharmacokinetic-pharmacodynamic modeling of antihypertensive drugs. For this purpose, we studied the antihypertensive ...
Application of microdialysis for pharmacokinetic-pharmacodynamic modelling
(Informa Healthcare, 2006-09)
Pharmacokinetic–pharmacodynamic (PK–PD) modelling describes the relationship between the pharmacokinetics and pharmacodynamics of a drug allowing the prediction of clinically relevant parameters. PK–PD modelling has several ...
Comparison of different pharmacodynamic models for PK-PD modeling of verapamil in renovascular hypertension
(Elsevier, 2008-05)
Introduction: The aim of this work was to compare the suitability of different pharmacodynamic models for PK-PD modeling of verapamil cardiovascular effects in aortic coarctated rats (ACo), a model of renovascular hypertension. ...
Mechanism of action of drugs with activity against multicellular parasites
(Nauka, 2017-03)
Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, ...
Failure of ivermectin efficacy against Psoroptes ovis infestation in cattle: Integrated pharmacokinetic-pharmacodynamic evaluation of two commercial formulations
(Elsevier Science, 2018-11)
Psoroptic mange is an important parasitic disease that mainly affects beef cattle producing marked economic losses. Ivermectin (IVM) is considered one of the most effective treatments against psoroptic mange and is used ...
Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
(Assoc Avian Veterinarians, 2013-09)
To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and ...
Pharmacokinetic study of propofol in horsesEstudio farmacocinético de propofol en equinos
(Archivos de Medicina Veterinaria, 1998)