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THE PROTO-ONCOGENE RAS IN MULTINODULAR GOITERO PROTO-ONCOGENE RAS NO BÓCIO MULTINODULAR
(HCPA/FAMED/UFRGS, 2022)
Human papillomavirus DNA and oncogene alterations in colorectal tumors
(Springer, 2010-09)
The aim of the present study is to determine the presence and molecular integrity of high-risk HPV types in colorectal adenocarcinomas and to assess whether viral DNA is related to common proto-oncogene alterations, such ...
Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease
(Nature Publishing Group, 2014-05)
R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical ...
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice
(Oxford University Press, 2013-10)
Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving ...
Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model
(American Association for Cancer Research, 2009-05)
Head and neck squamous cell carcinomas (HNSCC), the majority of which occur in the oral cavity, remain a significant cause of morbidity and mortality worldwide. Amajor limitation in HNSCC research has been the paucity of ...