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Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases
(Bentham Science Publishers, 2018-07)
Neglected diseases comprise a number of infectious diseases historically endemic to low-and middle-income countries, though recently they have spread to high-income countries due to human migrations. In the past, pharmaceutical ...
Polyamines and related nitrogen compounds in the chemotherapy of neglected diseases caused by kinetoplastids
(Bentham Science Publishers, 2018-05)
Neglected diseases due to the parasitic protozoa Leishmania and Trypanosoma (kinetoplastids) affect millions of people worldwide, and the lack of suitable treatments has promoted an ongoing drug discovery effort to identify ...
Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases
(Editions Sante, 2021-12)
Despite all the advances in understanding the pathogenesis of infectious diseases and the development of novel treatments to combat them, these pathogenic disorders are among the most common reasons for hospitalizations ...
Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes
(Elsevier, 2019-04)
Cestode parasites cause neglected diseases, such as echinococcosis and cysticercosis, which represent a significant problem in human and animal health. Benzimidazoles and praziquantel are the only available drugs for ...
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review
(Elsevier Science, 2019-10)
Neglected tropical diseases (NTDs) constitute a group of infectious diseases prevalent in countries with tropical and subtropical climate that affect the poorest individuals and produce high chronic disability associated ...
Tropical and Subtropical Parasitic Diseases: Targets for a New Approach to Virtual Screening
(Wiley-VCH, 2019-11)
Computational techniques are widely used toreduce costs associated with new drug development withthe ability to bind a specific molecular target. These studiesneed a Brookhaven protein data bank structure sample ofthe ...
Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control
(Elsevier Science, 2020-05)
Chagas disease is currently endemic to 21 Latin-American countries and has also become a global concern because of globalization and mass migration of chronically infected individuals. Prophylactic and therapeutic vaccination ...
Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina
(Open Learning on Enteric Pathogens, 2013-08)
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi. Most of the infections ...
Chagas Disease across Contexts: Scientific Knowledge in a Globalized World
(Routledge, 2021-07)
Chagas es la enfermedad endémica más importante de América Latina. Se construyó progresivamente como una cuestión pública relevante, comenzando como un problema médico, centrándose después en las condiciones de vivienda, ...
Inequalities in the social determinants of Chagas disease in indigenous and creole people in the Argentine Chaco
(BioMed Central, 2019-06)
Background: The social determinants of health (SDHs) condition disease distribution and the ways they are handled. Socio-economic inequalities are closely linked to the occurrence of neglected tropical diseases, but empirical ...