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miRNA Biogenesis: A Dynamic Pathway
(Cell Press, 2016-12)
MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to ...
Keep calm and carry on: miRNA biogenesis under stress
(Wiley Blackwell Publishing, Inc, 2019-06)
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. Their biogenesis relies on the cleavage of longer precursors by a nuclear localized processing machinery. The evolutionary preference of plant ...
Identification of key sequence features required for microRNA biogenesis in plants
(Nature Publishing Group, 2020-10)
MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. In plants, the ...
Multiple RNA recognition patterns during microRNA biogenesis in plants
(Cold Spring Harbor Lab Press, 2013-10)
MicroRNAs (miRNAs) derive from longer precursors with fold-back structures. While animal miRNA precursors have homogenous structures, plant precursors comprise a collection of fold-backs with variable size and shape. Here, ...
HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
(Oxford University Press, 2021-03)
HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, ...
MicroRNA expression profile in murine central nervous system development
(Humana Press IncTotowaEUA, 2008)
Efficiency and precision of microRNA biogenesis modes in plants
(Oxford University Press, 2018-07)
Many evolutionarily conserved microRNAs (miRNAs) in plants regulate transcription factors with key functions in development. Hence, mutations in the core components of the miRNA biogenesis machinery cause strong growth ...
Regulación post-traduccional de la proteína HYL1 y su impacto en la biogénesis de Micro ARNs
(2021-08-18)
Las plantas, como organismos foto-autótrofos y sésiles, deben superar las fluctuaciones ambientales, entre ellos la cantidad y calidad de luz, que desafian su supervivencia. Para esto, las mimas reprograman su desarrollo ...
The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity
(American Society of Plant Biologist, 2020-07)
In plants, small RNAs (sRNA) are loaded into ARGONAUTE (AGO) proteins to fulfill their regulatory functions. Micro RNAs (miRNAs), one of the most abundant classes of endogenous sRNAs, are preferentially loaded into ARGONAUTE1 ...