Artículos de revistas
miRNA Biogenesis: A Dynamic Pathway
Fecha
2016-12Registro en:
Achkar, Natalia Patricia; Cambiagno, Damián Alejandro; Manavella, Pablo Andrés; miRNA Biogenesis: A Dynamic Pathway; Cell Press; Trends In Plant Science; 21; 12; 12-2016; 1034-1044
1360-1385
CONICET Digital
CONICET
Autor
Achkar, Natalia Patricia
Cambiagno, Damián Alejandro
Manavella, Pablo Andrés
Resumen
MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.