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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
(Pergamon-Elsevier Science Ltd, 2004-04)
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases ...
Insights into the Interactions between Maleimide Derivates and GSK3 beta Combining Molecular Docking and QSAR
(PUBLIC LIBRARY SCIENCE, 2014)
Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
(2018-01-01)
Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are ...
In silico approaches to develop new phenyl-pyrimidines as glycogen synthase kinase 3 (GSK-3) inhibitors with halogen-bonding capabilities : 3D-QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies
(2023)
Glycogen synthase kinase 3 (GSK-3) is involved in different diseases, such as manic-depressive illness, Alzheimer’s disease and cancer. Studies have shown that insulin inhibits GSK-3 to keep glycogen synthase active. ...
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3
(Taylor & Francis Ltd, 2019-01)
Numerous studies have highlighted the implications of the glycogen synthase kinase 3 (GSK-3) in several processes associated with Alzheimer’s disease (AD). Therefore, GSK-3 has become a crucial therapeutic target for the ...
Downhill Running-based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway Without Concomitant Decrease Of Inflammatory Proteins
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2015)
Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles
(COMPANY OF BIOLOGISTS LTD, 2009)
Tail regeneration in Xenopus tadpoles is a favorable model system to understand the molecular and cellular basis of tissue regeneration. Although turnover of the extracellular matrix (ECM) is a key event during tissue ...