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Prevalence of the germline TP53 p.R337H mutation in families with multiple cases of cancer
(Universidade Estadual Paulista (Unesp), 2013)
Germline mutations in TP53 gene are associated with Li-Fraumeni syndrome (LFS) and its variants Li-Fraumeni-like (LFL). They predispose carriers to a wide variety of early onset tumors. In Brazil, there is a high frequency ...