Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...

This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the ...

The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release ...

The pharmacokinetics of an anthelmintic drug includes the time course of drug absorption, distribution, metabolism and elimination from the host and determines the concentration of the active drug that reaches the location ...

The present study correlates the structure of an albumin nanoparticle with its function as a drug delivery system. The albumin nanoparticle was created by a clean and size-controlled desolvation method in combination with ...

A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium ...

We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...

The term drug design describes the search of novel compounds with biological activity, on a systematic basis. In its most common form, it involves modification of a known active scaffold or linking known active scaffolds, ...

Today computational chemistry is a consolidated tool in drug lead discovery endeavors. Due to methodological developments and to the enormous advance in computer hardware, methods based on quantum mechanics (QM) have gained ...

Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease ...