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ESTUDO DO LORMETAZEPAM COMO HIPNOINDUTOR
(1983-12-01)
High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease
(Bentham Science Publishers, 2015-03)
Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas disease are still limited to two drugs, nifurtimox and benznidazole, ...
Interaction between areas of the central nervous system in the control of water intake and arterial pressure in rats
(1984-01-01)
1. Water intake induced by injection of 0.2 M-NaCl into the lateral preoptic area was increased by the injection of angiotensin II into the subfornical organ of rats. The injection of hypertonic saline solution into the ...
Practical and regulatory considerations for stability-indicating methods for the assay of bulk drugs and drug formulations
(Elsevier, 2013-09)
As part of the overall analytical control strategy, current regulations require stability-indicating methods (SIMs) to demonstrate product integrity until the re-test period of drug substances (DSs) or throughout the shelf ...
Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery
(2013-01-02)
In this work pellets containing chitosan for colonic drug delivery were developed. The influence of the polysaccharide in the pellets was evaluated by swelling, drug dissolution and intestinal permeation studies. Drug-loaded ...
Sistemas biodegradáveis contendo acetato de prednisolona para administração orbitária
(2009-07-01)
Purpose: The present study aimed to evaluate an injectable extended-release formulation of prednisolone acetate (PA) for orbital administration. Methods: Microspheres (MEs) of poly-ε-caprolactone (PCL) containing PA were ...
Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital
(Universidade de São Paulo (USP), Faculdade de Medicina, 2014-03-01)
OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to ...
Diuréticos em pediatria
(1978-01-01)