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Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip
(2020)
The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema remain unknown. In an exciting new ...
Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools
(Cell Press, 2016-11)
Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for regenerating the patterned skeleton during axolotl appendage regeneration. This complexity has made it difficult to identify the cells that ...
Progressive specification rather than intercalation of segments during limb regeneration
(American Association for the Advancement of Science, 2013-12)
An amputated salamander limb regenerates the correct number of segments. Models explaining limb regeneration were largely distinct from those for limb development, despite the presence of common patterning molecules. ...
Axial regeneration in segmented animals: A post-embryonic reboot of the segmentation process
(CRC Press - Taylor & Francis Group, 2020)
Axial regeneration, the ability to regrow structures along the main body axis, is a widespread, likely ancestral trait of metazoans. Despite its assumed adaptive value, regenerative ability has decreased, disappeared and ...