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Progression to degenerative dementia in mild cognitive impairment patients: a cohort studyProgression to degenerative dementia in mild cognitive impairment patients: a cohort study
(Wiley, 2019)
Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the ...
Geriatric depression and alexithymia in family caregivers of patient with dementia: A cross sectional study
(Wiley, 2019)
Caring for patients with dementia is a stressful process for caregivers which increases the risk of physical and mental problems, among which depressive disorders stand out. Aim: To determine the prevalence and predictors ...
Progranulin c.709‐1g>a variant in an argentine family with behavioral variant frontotemporal dementia and semantic primary progressive aphasia
(Wiley, 2019)
Mutations in GRN are a frequent genetic cause of frontotemporal lobar degeneration. In this study we describe the finding of GRN variant c.709‐1G>A (p.Ala237fs) in an Argentine family of Basque origin with a history of ...
Rare missense variants in TREM2 and ABCA7 in a patient with sporadic early‐onset alzheimer's disease
(Wiley, 2019)
Alzheimer’s disease (AD) is a clinically heterogeneous neurodegenerative disease. Presentations of symptoms in individuals before the age of 65 years are classified as early-onset Alzheimer’s disease (EOAD). According to ...
Tau dysfunction in the basal ganglia of a mouse model of tauopathy related to PSP
(International Parkinson and Movement Disorder Society, 2016)
Objective: Determine motor coordination and neurochemical phenotypes in the basal ganglia of mice lacking the Tau protein or expressing an abnormal content of Tau isoforms.Background: Microtubule-associated protein TAU is ...
Cognitive decline and healthy aging: an online activities and psychoeducational program for older adults in the context of COVID-19 Pandemic: preliminary results
(Wiley, 2021)
AbstractBackground: The preventive and compulsory social isolation regulations due to COVID-19 affected the entire population, but this became more emphasized in the group of older adults. Many older adults who attended ...
Argentinian initiative for the study of down syndrome and alzheimer's disease (IASDA)
(Wiley, 2019)
Alzheimer's Disease (AD) is not only more frequent and has an earlier onset in Down Syndrome (DS) than in the general population, but also has an atypical clinical phenotype and an uncertain genetic risk factor and biomarker ...
Heart Rate Variability and Cognitive Impairment in Parkinson’s Disease
(Wiley, 2019)
Objective: To evaluate the association between the heart rate variability (HRV) and cognitive impairment in PD patients.Background: Emerging evidence suggests an association between cognitive impairment and autonomic ...
Galectin-1 improves cognition and reduces amyloid-β deposits in an animal model of Alzheimer's disease possibly by modulating microglia phenotype and increasing Aβ clearance
(Elsevier, 2019)
Alzheimer's disease (AD) is the most common form of dementia associated with an imbalanced production and clearance of amyloid-β peptides (Aβ). Amyloid deposition and neuroinflammation are recognized hallmarks in AD, ...
The role of physical activities and clinical risk factors on cognitive reserve: Preliminary results on an Argentine population of older adults
(Wiley, 2020)
Background: Lifestyle plays an important role in the way people age. In recent decades, increasing attention has been paid to the role ofleisure activities. Evidence from different studies, supports the hypothesis that ...