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Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
(SAFIS, 2010-11)
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial ...
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated with Sepsis
(Lippincott Williams, 2017-04)
Objectives: Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic reticulum Ca2+ loss that mediate altered ...
The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAUFMG, 2019-12-27)
Rab11 Regulates Trafficking of Trans-sialidase to the Plasma Membrane through the Contractile Vacuole Complex of Trypanosoma cruzi
(Public Library of Science, 2014-06)
Trypanosoma cruzi is the etiologic agent of Chagas disease. Although this is not a free-living organism it has conserved a contractile vacuole complex (CVC) to regulate its osmolarity. This obligate intracellular pathogen ...
Beta-adrenergic stimulation causes rapid nos1-dependent s-nitrosylation of cardiac proteins, associated with increased contractility
(FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, 2011)
The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Aims: Cytokines interfere with signaling pathways and mediators of vascular contraction. Endothelin-1 (ET-1) plays a major role on vascular dysfunction in conditions characterized by increased circulating levels of adipokines. ...
Intestine of dystrophic mice presents enhanced contractile resistance to stretching despite morphological impairment
(Amer Physiological Soc, 2014-02-01)
Protein dystrophin is a component of the dystrophin-associated protein complex, which links the contractile machinery to the plasma membrane and to the extra-cellular matrix. Its absence leads to a condition known as ...