Artículos de revistas
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Fecha
2010-11Registro en:
Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz; Phospholamban: a tiny protein with a prominent role in the regulation of cardiac
relaxation and contractility; SAFIS; Physiological Mini-Reviews; 5; 3; 11-2010; 8-17
1669-5402
1669-5410
CONICET Digital
CONICET
Autor
Mattiazzi, Ramona Alicia
Mundiña, Cecilia Beatriz
Vittone, Leticia Beatriz
Resumen
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.