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Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
(Elsevier, 2019-07)
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by ...
Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
(Remedy Publications, 2019-12)
The endocannabinoid system (ECS) is closely related to the central nervous system (CNS) and exerts a promising therapeutic potential on the cardiovascular system, mainly through its neuromodulatory, neuroprotective, and ...
Distribution and characterization of corazonin in the central nervous system of Triatoma infestans (Insecta: Heteroptera)
(Elsevier Science, 2011-03)
The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass ...
Severe Acute Respiratory Syndrome Coronavirus 2 Impact on the Central Nervous System: Are Astrocytes and Microglia Main Players or Merely Bystanders?
(SAGE Publications, 2020-09)
With confirmed coronavirus disease 2019 (COVID-19) cases surpassing the 18 million mark around the globe, there is an imperative need to gain comprehensive understanding of severe acute respiratory syndrome coronavirus 2 ...
Signaling within the pineal gland: A parallelism with the central nervous system
(Academic Press Ltd - Elsevier Science Ltd, 2018-12)
The pineal gland (PG) derives from the neural tube, like the rest of the central nervous system (CNS). The PG is specialized in synthesizing and secreting melatonin in a circadian fashion. The nocturnal elevation of melatonin ...
Current state and future perspectives in QSAR models to predict blood-brain barrier penetration in central nervous system drug R&D
(Bentham Science Publishers, 2017-02)
The Blood-Brain Barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability ...
Ablation of arginyl-tRNA-protein transferase in oligodendrocytes impairs central nervous system myelination
(Wiley-liss, div John Wiley & Sons Inc., 2021-10)
Addition of arginine (Arg) from tRNA can cause major alterations of structure and function of protein substrates. This post-translational modification, termed protein arginylation, is mediated by the enzyme arginyl-tRNA-protein ...
Histone methylations in the developing central nervous system and in neural tube defects
(De Gruyter, 2018-05)
Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms ...
Revisiting the anatomy of the central nervous system of a hemimetabolous model insect species: The pea aphid Acyrthosiphon pisum
(Springer, 2011-02)
Aphids show a marked phenotypic plasticity, producing asexual or sexual and winged or wingless morphs depending on environmental conditions and season. We describe here the general structure of the brain of various morphs ...