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Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
(Elsevier, 2020)
The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...
Mitochondria, myocardial remodeling, and cardiovascular disease
(2012)
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...
Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts
(Elsevier, 2020)
Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac ...
Molecular mechanisms of autophagy in the cardiovascular system
(Lippincott Williams and Wilkins, 2015)
Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that
is conserved from yeast to mammals. During autophagy diverse cytosolic constituents are
enveloped by double-membrane ...
IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells
(SOC ENDOCRINOLOGY, 2004-08)
We studied the effect of IGF-I and insulin on intracellular Ca2+ in primary cultured myotubes. IGF-I induced a fast and transient Ca2+ increase, measured as fluo-3 fluorescence. This response was blocked by both genistein ...
Cardiovascular autophagy concepts, controversies, and perspectives
(Taylor and Francis Inc., 2013)
Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been ...
Lipopolysaccharide activates toll like receptor 4 and prevents cardiac fibroblast to myofibroblast differentiation
(Springer, 2017)
Bacterial lipopolysaccharide (LPS) is a known ligand of Toll-like receptor 4 (TLR4) which is expressed in cardiac fibroblasts (CF). Differentiation of CF to cardiac myofibroblasts (CMF) is induced by transforming growth ...