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An inactive mutant of the α subunit of protein kinuse CK2 that traps the regulatory CK2β subunit
(1997)
Protein kinase CK2 (casein kinase 2) is a ubiquitous Ser/Thr protein kinase involved in cell proliferation. Mutation of the α subunit of the Xenopus laevis CK2 to change aspartic acid 156 to alanine (CK2αA156) resulted in ...
Resurrecting the regulatory properties of the ostreococcus tauri ADP-glucose pyrophosphorylase large subunit
(Frontiers Media S.A., 2018-10)
ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step for the synthesis of glycogen in cyanobacteria and starch in green algae and plants. The enzyme from cyanobacteria is homotetrameric (α4), ...
Charged amino acid motifs flanking each extreme of the αM4 transmembrane domain are involved in assembly and cell-surface targeting of the muscle nicotinic acetylcholine receptor
(Wiley-liss, Div John Wiley & Sons Inc, 2007-02-27)
The αM4 transmembrane domain of the nicotinic acetylcholine receptor (AChR) is flanked by two basic amino acids (His408 and Arg429) located at its cytoplasmic‐ and extracellular‐facing extremes, respectively, at the level ...
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans
(eLife Sciences Publications Ltd, 2019-08-05)
Mutations in pre-synaptic voltage gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or ...
A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function
(American Society for Biochemistry and Molecular Biology, 2011-01-28)
The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive ...
Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors
(Associação Brasileira de Divulgação Científica, 2010-05-01)
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium ...
Cry1 and GPA1 signaling genetically interact in hook opening and anthocyanin synthesis in Arabidopsis
(Springer, 2012-10)
While studying blue light-independent effects of cryptochrome 1 (cry1) photoreceptor, we observed premature opening of the hook in cry1 mutants grown in complete darkness, a phenotype that resembles the one described for ...