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Equilibrium mono- and multicomponent adsorption models: From homogeneous ideal to heterogeneous non-ideal binding
(Elsevier Science, 2020-06)
Aqueous sorption processes play an important role in, for example, pollutant binding to natural nanoparticles, colloid stability, separation and enrichment of components and remediation processes. In this article, which ...
Mapping the neurosteroid binding sites on glycine receptors
(Pergamon-Elsevier Science Ltd, 2019-09)
Glycine is a major inhibitory neurotransmitter in the CNS, where it modulates both sensory and motor transduction throughout its binding to glycine receptors (GlyRs), pentameric chloride channels that share structural and ...
Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel
(Elsevier Science Inc, 2002-07-01)
Previous studies have established the presence of overlapping binding sites for the noncompetitive antagonists (NCAs) amobarbital, tetracaine, and 3-trifluoromethyl-3-(m-[ 125 I]iodophenyl) diazirine ([ 125 I]TID) within ...
Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2000-06-01)
Identification of all residues involved in the recognition and binding of cholinergic ligands (e.g. agonists, competitive antagonists, and noncompetitive agonists) is a primary objective to understand which structural ...
The structure of unliganded sterol carrier protein 2 from Yarrowia lipolytica unveils a mechanism for binding site occlusion
(Academic Press Inc Elsevier Science, 2021-03-02)
Isolated or as a part of multidomain proteins, Sterol Carrier Protein 2 (SCP2) exhibits high affinity and broad specificity for different lipidic and hydrophobic compounds. A wealth of structural information on SCP2 domains ...
Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2001-05)
Although the dissociative anesthetic dizocilpine [(+)-MK-801] inhibits nicotinic acetylcholine receptor (AChR) function in a noncompetitive manner, the location of the dizocilpine binding site(s) has yet to be clearly ...
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
(American Physical Society, 2017-04)
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for ...
Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors
(Society for Neuroscience, 2009)
Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves
(Public Library of Science, 2020-06-04)
Negative cooperativity is a phenomenon in which the binding of a first ligand or substrate molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand-receptor binding, it holds whenever ...
Allele-specific methylation of a functional CTCF binding site upstream of MEG3 in the human imprinted domain of 14q32
(Springer, 2005-12)
The gene MEG3 is located in the imprinted human chromosomal region on 14q32. Imprinting of a structurally homologous region IGF2/H19 on 11p15 is mediated through cytosine methylation-controlled binding of the protein CTCF ...