Buscar
Mostrando ítems 1-10 de 10
Excitotoxicity as a target against neurodegenerative processes
(Bentham Science Publishers, 2020)
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway
(2012)
Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
(Elsevier, 2011-04)
The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...
Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide
(ELSEVIER INC, 2008)
CD95 (Fas/Apo-1)-mediated apoptosis was shown to occur through two distinct pathways. One involves a direct activation of caspase-3 by large amounts of caspase-8 generated at the DISC (Type I cells). The other is related ...
Papel do miR-23b e miR-133a no controle de expressão de componentes da via TRAIL de apoptose em células de adenocarcinoma de pulmão (A549) e carcinoma renal (CaKi-2) e na sensibilização de células A549 ao TRAIL
(Universidade Federal de São Paulo, 2023-04-18)
Introdução: A despeito dos avanços nas terapias antineoplásicas, desenvolvimento
de resistência tumoral é um dos principais desafios no tratamento do câncer. A via de
apoptose desencadeada pelo TRAIL é potencial alvo ...
Fatty Acid Synthase Inhibitors Induce Apoptosis In Non-tumorigenic Melan-a Cells Associated With Inhibition Of Mitochondrial Respiration
(Public Library of Science, 2014)