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Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
(Colegio de Farmacéuticos de la Provincia de Buenos Aires, 2011-11)
Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more ...
Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
(American Society for Microbiology, 2018-05)
Chromoblastomycosis (CBM) is a recalcitrant fungal skin disease which is difficult to treat, the infection leading to excessive proliferation of host tissues. Therefore, search for appropriate antifungal strategies is ...
Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
(Oxford University Press, 2019-05)
BACKGROUND: Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as ...
Silver nanoparticles with high loading capacity of amphotericin B: Characterization, bactericidal and antifungal effects
(Bentham Science Publishers B.V., 2017-09)
The purpose of this study was to evaluate the most appropriate conditions to generate silver nanoparticles (AgNPs) loaded with a potent antimycotic drug like amphotericin B (AmB), characterize the physicochemical properties, ...
Self-assembled Amphotericin B Pharmacosome like Vesicles Derived from Lipid-based Microtubes: a Model Carrier to Further Explore
(Bentham Science Publishers, 2020-07)
Background: Self-assembled drug delivery systems are of much interest since they can be produced by simple low cost and solvent-free procedures. Pharmacosomes are supramolecular-structured nanocarriers with benefits for ...
Synergic activity of oligostyrylbenzenes with amphotericin B against Candida tropicalis biofilms
(John Wiley & Sons Ltd, 2021-10-01)
Antimicrobial drug resistance is a serious challenge in clinical settings worldwide, with biofilm formation having been associated with this problem. In the present study, the synergism of oligostyrylbenzene (OSB) compounds ...
Antifungal susceptibility of malassezia furfur, malassezia sympodialis and malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method
(Taylor & Francis Ltd, 2014-08)
We studied the in vitro activity of fluconazole (FCZ), ketoconazole (KTZ), miconazole (MCZ), voriconazole (VCZ), itraconazole (ITZ) and amphotericin B (AMB) against the three major pathogenic Malassezia species, M. globosa, ...
In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Galleria mellonella Model of Mucormycosis
(Multidisciplinary Digital Publishing Institute, 2019-01)
Mucorales are resistant to most antifungals. Mucormycosis associated mortality is unacceptable and new treatment approaches are needed. The objectives of this work were (i) to evaluate the nature and intensity of the in ...
Etest ECVs/ECOFFs for detection of resistance in prevalent and three nonprevalent Candida spp. To triazoles and amphotericin b and aspergillus spp. To caspofungin: further assessment of modal variability
(American Society for Microbiology, 2021-11)
Susceptibility testing is an important tool in the clinical setting; its utility is based on the availability of categorical endpoints, breakpoints (BPs), or epidemiological cutoff values (ECVs/ECOFFs). CLSI and EUCAST ...
Identification of Candida parapsilosis Sensu Lato in Pediatric Patients and Antifungal Susceptibility Testing
(American Society for Microbiology, 2017-07)
A total of 59 Candida parapsilosis sensu stricto and 1 Candida orthopsilosis recovered from catheters and blood cultures of pediatric patients from the northeastern region of Argentina were studied. Susceptibility to azoles, ...