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N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
(Planta Piloto de Ingeniería Química, 2019-08)
The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release ...
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures
(Universidad Militar Nueva Granada, 2016)
Liposomes containing cyclodextrins or meglumine to solubilize and improve the bioavailability of poorly soluble drugs
(Elsevier Science, 2017-03-19)
Poorly soluble drug-loaded liposomes are well known for their ability to solubilize and improve the bioavailability of the carried molecules, and may provide benefits as oral drug delivery systems. In this work, we aim to ...
High throughput method to characterize acid-base properties of insoluble drug candidates in water
(Elsevier Science, 2018-05)
In drug design experimental characterization of acidic groups in candidate molecules is one of the more important steps prior to the in-vivo studies. Potentiometry combined with Yasuda-Shedlovsky extrapolation is one of ...
Synthesis and characterization of a new cyclodextrin derivative with improved properties to design oral dosage forms
(Springer Verlag Berlín, 2019-02)
This work aimed to synthesize a novel β-cyclodextrin derivative, itaconyl-β-cyclodextrin to evaluate whether albendazole inclusion complexes with the new β-cyclodextrin derivative-improved albendazole dissolution efficiency ...
Influence of water uptake, gel network, and disintegration time on prednisone release from encapsulated solid dispersions
(Taylor & Francis, 2010-09)
Prednisone is considered the glucocorticoid of choice for anti-inflammatory and immunosuppressant effects. However, its very low aqueous solubility can compromise oral bioavailability. Changes in the dissolution of a ...
Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate
(Elsevier, 2019-11-13)
Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water ...
Prediction of the aqueous solubility of diverse compounds by 2D-QSPR
(Elsevier Science, 2020-03)
Non conformational QSPR models were built for the aqueous solubility (mol/L) at 25 °C of 5610 structurally heterogeneous compounds, including pesticides, drugs and solvents, among others, with a wide range of aqueous ...
Novel techniques for drug loading quantification in mesoporous SBA-15 using chemometric-assisted UV and FT-IR data
(Elsevier Science, 2022-07-15)
Albendazole is a crystalline drug that is poorly soluble in water, thus the dissolution rate in gastrointestinal fluids is limited. Mesoporous materials loaded with poorly water-soluble drugs become an interesting strategy ...