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Clinicopathological significance of ERCC1 expression in breast cancer
(2013-06-01)
The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway and is associated with resistance to platinum-based chemotherapy in different types of cancer. ...
Primary relapse site pattern in women with triple-negative breast cancer
(Elsevier B.V., 2014-01-01)
Despite the remarkable improvements in breast cancer (BC) characterization, accurate prediction of BC clinical behavior is often still difficult to achieve. Some studies have investigated the association between the molecular ...
Triple-negative breast carcinomas are a heterogeneous entity that differs between young and old patients
(Faculdade de Medicina / USP, 2010)
OBJECTIVE: To compare the frequency and immunohistochemical profiles of triple-negative breast carcinomas in younger and older women. METHODS AND RESULTS: We selected patients diagnosed with triple-negative breast carcinomas. ...
The role of melatonin on miRNAs modulation in triple-negative breast cancer cells
(Public Library Science, 2020-02-03)
Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effects by reducing tumor cell proliferation, migration and invasion. MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulation ...
The trans-[Ru(PPh3)(2)(N,N-dimethyl-N '-thiophenylthioureato-k(2)O,S)(bipy)] PF6 complex has pro-apoptotic effects on triple negative breast cancer cells and presents low toxicity in vivo
(Elsevier B.V., 2018-09-01)
Triple negative breast cancer (TNBC) is a heterogeneous subtype of breast tumors that does not exhibit the expression of estrogen and progesterone receptors, neither the amplification of the human epidermal growth factor ...
[10]-Gingerol-Loaded Nanoemulsion and its Biological Effects on Triple-Negative Breast Cancer Cells
(Springer, 2021-05-18)
The apoptotic, cytotoxic, and cytostatic activities for [10]-gingerol in triple-negative breast cancer cells (TNBCs) were already reported. However, despite these important antitumor activities, the compound has the ...
Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo
(2018-09-01)
Breast Cancer (BC) is a highly heterogeneous disease whose most aggressive behavior is displayed by triple-negative breast cancer (TNBC), which lacks an efficient targeted therapy. Despite its controversial role, one of ...
Geographic differences in the distribution of molecular subtypes of breast cancer in Brazil
(BMC, 2014-08-29)
Abstract
Background
To compare the distribution of the intrinsic molecular subtypes of breast cancer based on immunohistochemical profile in the five major geographic regions ...
Histamine H4 receptor : insights into a potential therapeutic target in breast cancer
(2015)
Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer
death in women. Several studies underlined the critical role of histamine in breast cancer development and
progression. ...