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Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth
(Elsevier Science Inc, 2012-03)
Transforming growth factor beta 1 (TGF-β1) has been implicated in the pathogenesis of prostate cancer (PCa) bone metastasis. In this study, we tested the antitumor efficacy of a selective TGF-β receptor I kinase inhibitor, ...
Active and Total Transforming Growth Factor-{beta}1 are Differentially Regulated by Dopamine and Estradiol in the Pituitary
(Endocrine Society, 2011-07)
Dopamine, acting through the dopamine type 2 receptor (Drd2), is the main inhibitor of pituitary prolactin (PRL) secretion and lactotroph proliferation. TGF-β1 is involved, at least in part, in mediating these actions. It ...
Staphylococcus aureus chronic intramammary infection modifies protein expression of transforming growth factor beta (TGF-β) subfamily components during active involution
(2014-02)
The objectives of this study were to determine whether Staphylococcus aureus chronic intramammary infection (IMI) influences protein expression of TGF-β subfamily components and collagen I and to examine the histomorphometric ...
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferationParticipación de la vía de señalización AKT/mTORC1 en la proliferación de las células β del páncreas
(Universidad del ValleGenética Molecular (GENMOL)Cali, Colombia, 2021)
The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
(Academic Press Inc Elsevier Science, 2010-03)
We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic ...
Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig cell proliferation
(Academic Press Ltd - Elsevier Science Ltd, 2013-02)
Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine that modulates cell homeostasis. In Leydig cells, TGF-β1 exerts stimulatory and inhibitory effect depending on the type I receptor involved in the signaling ...
VIP and tolerance induction in autoimmunity
(Blackwell Publishing, 2006-12)
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with ...
The effector protein BPE005 from Brucella abortus induces collagen deposition and matrix metalloproteinase 9 downmodulation via transforming growth factor β1 in hepatic stellate cells
(American Society for Microbiology, 2015-12)
The liver is frequently affected in patients with active brucellosis. In the present study, we identified a virulence factor involved in the modulation of hepatic stellate cell function and consequent fibrosis during ...