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In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae
(Pergamon-Elsevier Science Ltd, 2018-03)
Epilepsy is a neurological disorder treated with antiepileptic drugs (AEDs). Since AEDs are administered in women in childbearing age, it is critical to study if drugs are capable of inducing developmental toxicity. Along ...
The role of teratogens in neural crest development
(Wiley-liss, div John Wiley & Sons Inc., 2020-01)
The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development ...
Methodological Approaches to Evaluate Teratogenic Risk Using Birth Defect Registries: Advantages and Disadvantages
(Public Library of Science, 2012-10)
Background: Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ...
Toxicity characterization and environmental risk assessment of Mancozeb on the South American common toad Rhinella arenarum
(Springer Heidelberg, 2019-12)
Agricultural activity, especially the increasing use of pesticides, is considered one of the main reasons for the decline of amphibian populations. Mancozeb (MCZ) is one of the most used fungicides worldwide, despite its ...
Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model
(Academic Press Inc Elsevier Science, 2015-04)
With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied. Anurans, ...
Abnormalities in amphibian populations inhabiting agroecosystems in northeastern Buenos Aires Province, Argentina
(Inter-Research, 2013-05-27)
The occurrence of abnormalities in amphibians has been reported in many populations, and its increase could be related to environmental pollution and habitat degradation. We evaluated the type and prevalence of abnormalities ...
Morphological abnormalities in natural populations of the common South American toad Rhinella arenarum inhabiting fluoride-rich environments
(Academic Press Inc Elsevier Science, 2019-08)
Morphological abnormalities in amphibians may be attributed to contaminants, ultraviolet radiation and trematode parasites, or a synergistic effect between them. In the present study, morphological abnormalities in Rhinella ...
Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling
(American Chemical Society, 2010-10)
The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has been ongoing controversy regarding the possible adverse effects of glyphosate on the environment and on human health. Reports of ...
Nanomaterials toxicity and teratogenicity in aquatic environment using Rhinella arenarum model
(Elsevier Ireland, 2016-10)
Nanotechnology is growing at an exponential rate and will undoubtedly have both beneficial and toxicological impact and consequences on health and environment. Amphibians are being increasingly used for toxicity screening ...
Developmental Toxicity Assessment of a Chlorothalonil-Based Fungicide in a Native Amphibian Species
(Springer, 2020-04)
The toxicity of a commercial formulation of the fungicide chlorothalonil in sensitive stages of the native amphibian Rhinella arenarum (Ra) was assessed by means continuous treatments from embryo and larval development and ...