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Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma
(Kluwer Academic/plenum Publ, 2003-05)
The purpose of this study was to evaluate the effect of the selective estrogen receptor modulators raloxifene and tamoxifen and of the pure antiestrogen fulvestrant on tumor growth and progesterone receptor (PR) expression ...
Fatty acid synthase confers tamoxifen resistance to ER+/HER2+ breast cancer
(Multidisciplinary Digital Publishing Institute, 2021-03)
Overactivation of the human epidermal growth factor receptor 2 (HER2) is one of the main drivers of tamoxifen resistance in estrogen receptor (ER)-positive breast cancer patients. Combined targeting of HER2 and ER, however, ...
Electrophysiological effects of tamoxifen: mechanism of protection against reperfusion arrhythmias in isolated rat hearts
(Lippincott Williams, 2013-08)
Reperfusion arrhythmias are currently attributed to ionic imbalance and oxidative stress. Tamoxifen is a potent antioxidant that also modulates some ionic transport pathways. In this work, we tried to correlate the ...
AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells
(Wiley-liss, Div John Wiley & Sons Inc, 2018-01)
More than 40% of patients with luminal breast cancer treated with endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt ...
Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process
(Academic Press Inc Elsevier Science, 2019-08-27)
This study shows the effects of tamoxifen, a known estrogen receptor antagonist used in the treatment of breast cancer, on the sphingolipid pathway of Trypanosoma cruzi, searching for potential chemotherapeutic targets. A ...
Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum
(Academic Press Inc Elsevier Science, 2018-03-18)
Parasites of the genus Plasmodium responsible for Malaria are obligate intracellular pathogens residing in mammalian red blood cells, hepatocytes, or mosquito midgut epithelial cells. Regarding that detailed knowledge on ...
Stromal-epithelial interactions and tamoxifen resistanceInteracciones estroma-epitelial al tamoxifeno
(Medicina (Buenos Aires), 2007-12)
Tamoxifen, a selective estrogen receptor modulator, is the standard endocrine treatment for hormone receptor positive breast cancer, both in the initial adjuvant therapy and as treatment of patients with metastatic disease. ...
A spontaneous estrogen dependent, tamoxifen sensitive mouse mammary tumor: A new model system to study hormone-responsiveness in immune competent mice
(Springer, 2009-01)
Currently, an in vivo spontaneous model of estrogen dependent, tamoxifen sensitive breast cancer does not exist. We show here the characterization of the M05 mammary tumor that appeared spontaneously in a 1-year-old virgin ...
In Vitro and In Vivo Effects of Tamoxifen against Larval Stage Echinococcus granulosus
(American Society for Microbiology, 2014-09)
Cystic echinococcosis is a zoonotic infection caused by the larval stage of the cestode Echinococcus granulosus. Chemotherapy currently employs benzimidazoles; however, 40% of cases do not respond favorably. With regard ...