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Inactivation of Trypanosoma cruzi and Crithidia fasciculata topoisomerase I by Fenton systems
(Maney Publishing, 2003-04)
Fenton systems (H2O2/Fe(II) or H2O2/Cu(II)) inhibited Trypanosoma cruzi and Crithidia fasciculata topoisomerase I activity. About 61-71% inactivation was produced by 25 μM Fe(II) or Cu(II) with 3.0 mM H2O2. Thiol compounds ...
Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice
(Wiley-liss, Inc, 2002-12)
In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin ...
DNA-PKcs-dependent NHEJ pathway supports the progression of topoisomerase II poison-induced chromosome aberrant cells
(Wiley-liss, Div John Wiley & Sons Inc, 2012-10)
The role of DNA double strand break (DSB) repair pathways, non-homologous end joining (NHEJ), and homologous recombination (HR) was evaluated to prevent the chromosome instability induced by the topoisomerase II (Top2) ...
Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs
(Springer, 2011-04)
Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DNA damage and the inhibition of topoisomerase II, promoting apoptosis. AD ...
In silico study of Moxifloxacin derivatives with possible antibacterial activity against a resistant form of DNA gyrase from Porphyromonas gingivalis
(Pergamon-Elsevier Science Ltd, 2018-11)
We performed a homology modeling of the structure of a non-mutated and mutated Ser83→Phe DNA gyrase of Porphyromonas gingivalis. The model presented structural features conserved in type II topoisomerase proteins. We ...
Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes
(Elsevier Ireland, 2002-02)
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) are frequently used in cancer chemotherapy. The effects of these drugs on cultured normal human lymphocytes were studied ...
Citotoxicidad de la ß-lapachona: una o-naftoquinona con posibles usos terapéuticosCytotoxicity of ß-lapachone, an o-naphthoquinone with possible therapeutic use
(Medicina (Buenos Aires), 2001-01)
La ß-lapachona (ß-lap) es una o-naftoquinona extraída de la madera del lapacho. Las observaciones iniciales mostraron su acción inhibidora del crecimiento del sarcoma de Yoshida y del carcinosarcoma de Walker 256. La ß-lap ...
Evaluación de las Actividades Antioxidante y Antitopoisomerasa de Extractos de Plantas de la Ecorregión Cafetera Colombiana
(Universidad Militar Nueva Granada, 2015)
Evaluación biológica de una fracción de la esponja marina Topsentia ophiraphidites del Caribe colombiano
(Universidad de Córdoba, 2013)