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Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents
(Elsevier Science, 2016-02)
A series of related thalidomide derivatives (2-9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the ...
Osmotic stress sensitizes naturally resistant cells to TNF-alpha-induced apoptosis
(Nature Publishing Group, 2002-10)
Most cells are naturally resistant to TNF-alpha-induced cell death and become sensitized when NF-kappaB transactivation is blocked or in the presence of protein synthesis inhibitors that prevent the expression of anti-apoptotic ...
Effect of Anti-TNF-α on the Development of Offspring and Pregnancy Loss During Pregnancy in Rats
(Universidade Federal do Rio Grande do Sul, 2016)
Los anti-TNF y la progresión radiográfica en espondilitis anquilosanteThe anti-TNF and the radiological progression in ankylosing spondylitis
(Asociación Colombiana de ReumatologíaGrupo de Inmunología Celular e InmunogenéticaGrupo de Reumatología Universidad de Antioquia -GRUA-Bogotá, Colombia, 2022)
Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina
(Academic Press Ltd - Elsevier Science Ltd, 2018-09)
Diabetic retinopathy (DR) is the most common cause of blindness in the working age population. Early events of DR are accompanied by neurodegeneration of the inner retina resulting in ganglion cell loss. These findings ...
La actividad transcripcional de NF-kB es diferencialmente regulada por dominios específicos del coactivador TIF2Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-κB transactivation
(Medicina (Buenos Aires), 2004-02)
Demostramos previamente que la sobreexpresión de coactivadores de receptores nucleares aumenta la actividad NF-κB en forma dosis dependiente. Se estudió el mecanismo por el cual el coactivador TIF2 regula la actividad de ...