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Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1
(Spandidos Publications, 2014)
The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification ...
Melatonin treatment combined with TGF-β silencing inhibits epithelialmesenchymal transition in CF41 canine mammary cancer cell line
(2020-01-01)
Background: Mammary cancer is the most prevalent type of cancer in female dogs. The main cause of mortality is the occurrence of metastasis. The metastatic process is complex and involves the EpithelialMesenchymal Transition ...
TGF-β and new bone formation
(2006-09-01)
The aim of this work is to present, by a literature review, the principal characteristics of TGF-beta, in the regulation and new bone formation. © 2007 Sociedad Chilena de Anatomía.
COX-2 and TGF-β expression in proliferative disorders of canine prostate
(2010-05-01)
COX-2 and TGF-β expression was determined in order to correlate non-neoplastic lesions, preneoplastic lesions and carcinoma in the prostate of dogs. The results show that neoplastic and preneoplastic lesions express more ...
SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
(2012)
Transforming growth factor-β1 (TGF-β1) stimulates the extracellular matrix degrading proteases expression and cell migration in order to enhance cancer cells malignancy. In the present study, we analysed the role of ...
Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
(Elsevier Ireland, 2017-01)
Ovarian cancer is characterized by being highly metastatic, a feature that represents the main cause of failure of the treatment. This study investigated the effects of γ-secretase inhibition on the TGF-β-induced ...
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
(2013)
Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...
Fibrillar collagen genes are not coordinately upregulated with TGF β1 expression in finasteride-treated prostate
(2017-11-01)
Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in older men. In this regard, recent studies have attempted to define the relationships between prostatic fibrosis, LUTS, ...
Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells
(Springer Verlag, 2016)
© 2015, The Author(s).Purpose: One of the hypotheses regarding the genesis of epithelial ovarian cancer involves the action of androgens on the proliferation of epithelial ovarian cells, as well as inclusion cysts. The ...
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
(Nature Publishing Group, 2013-09)
In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis. This suggested that the BM might be a metastasis ‘restrictive ...