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Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug surarnin
(Elsevier B.V., 2005-07-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom
(Elsevier B.V., 2004-12-01)
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was ...
Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by surarnin
(Elsevier B.V., 2003-09-15)
Polyanionic substances are known to inhibit the myotoxic effects of some crotalide snake venoms. Bothropstoxin-I (BthTX-I), a basic Lys49 phospholipase (PLA(2)) homologue from Bothrops jararacussu venom, besides inducing ...
Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom
(Bentham Science Publ Ltd, 2008-09-01)
Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its ...
Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intake
(Elsevier B.V., 2011-02-04)
Purinergic receptors are present in the lateral parabrachial nucleus (LPBN), a pontine structure involved in the control of sodium intake. In the present study, we investigated the effects of alpha,beta-methyleneadenosine ...
Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin
(International Union of Crystallography, 2015)
Interfacial surface charge and free accessibility to the PLA(2)-active site-like region are essential requirements for the activity of Lys49 PLA(2) homologues
(Elsevier B.V., 2007-03-01)
Lys49 phospholipase A(2) homologues are highly myotoxic and cause extensive tissue damage but do not display hydrolytic activity towards natural phospholipids. The binding of heparin, heparin derivatives and polyanionic ...
Effects of endothelin ETB receptor agonists and antagonists on the biphasic response in the ileum
(Elsevier B.V., 1999-03-19)
In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu(9),Ala(11,15)]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. ...
Differential regulation of atrial contraction by P1 and P2 purinoceptors in normotensive and spontaneously hypertensive rats
(Nature Publishing Group, 2014-03-01)
In the normotensive rat atrium, adenosine-5'-triphosphate and uridine-5'-triphosphate exert a biphasic effect consisting of an initial negative inotropic effect (NIE) followed by a subsequent positive inotropic effect ...