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Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
(Associação Brasileira de Divulgação Científica, 2012)
The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...
Catastrophic unbalanced genome rearrangements cause somatic loss of berry color in grapevine
(American Society of Plant Biologist, 2017-08)
Grape color somatic variants that can be used to develop new grapevine cultivars occasionally appear associated to deletion events of uncertain origin. To understand the mutational mechanisms generating somatic structural ...
Protective Effects of New Medicinal Mushroom Grifola gargal Singer (Higher Basidiomycetes), on Induced DNA Damage in Somatic cells of Drosophila melanogaster
(Begell House Inc, 2011-12)
Grifola gargal is an edible mushroom with attributed antioxidant properties. Different sources of G. gargal materials, i.e., fruit bodies and mycelia grown in liquid or solid media, were used to study its potential protective ...
Uncommon RB1 somatic mutations in a unilateral retinoblastoma patientMutaciones somáticas raras en un paciente con retinoblastoma unilateral
(Medicina (Buenos Aires), 2015-06)
Retinoblastoma (RB) is the most common primary intraocular malignancy in children. Somatic inactivation of both alleles of the RB1 tumor suppressor gene in a developing retina is a crucial event in the initiation of ...
Methylation patterns revealed by MSAP profiling in genetically stable somatic embryogenic cultures of Ocotea catharinensis (Lauraceae)
(SPRINGER, 2010)
Ocotea catharinensis is a rare tree species indigenous to the Atlantic rainforest of South America. In spite of its value as a hardwood species, it is in danger of extinction. The species erratically produces seeds showing ...
The effect of the dibenzylbutyrolactolic lignan (-)-cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
The dibenzylbutyrolactolic lignan (-)-cubebin was isolated from dry seeds of Piper cubeba L (Piperaceae). (-)-Cubebin possesses anti-inflammatory, analgesic and antimicrobial activities. Doxorubicin (DXR) is a topoisomer ...
The effect of the dibenzylbutyrolactolic lignan (-)-cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster
(Pergamon-Elsevier B.V. Ltd, 2011-06-01)
The dibenzylbutyrolactolic lignan (-)-cubebin was isolated from dry seeds of Piper cubeba L (Piperaceae). (-)-Cubebin possesses anti-inflammatory, analgesic and antimicrobial activities. Doxorubicin (DXR) is a topoisomer ...
Absence of mutagenic and recombinagenic activity of multi-walled carbon nanotubes in the Drosophila wing-spot test and Allium cepa test
(Academic Press Inc Elsevier ScienceSan DiegoEUA, 2014)
Chronic ethanol consumption in mice does not induce DNA damage in somatic or germ cells, evaluated by the bone marrow micronucleous assay and the dominant lethal mutation assay
(2012)
Although alcohol is known to be a carcinogen for humans, ethanol-genotoxicity studies are incomplete. Ethanol seems not to be a bacterial mutagen, but the results are conflicting in rodent assays. We investigate the ...