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The prodrug approach: A successful tool for improving drug solubility
(2016-01-01)
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their ...
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2006-06-01)
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and ...
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2006-06-01)
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and ...
Preparation of polymeric micelles for use as carriers of tuberculostatic drugs
(Pharmacotherapy Group, 2007-12-01)
Purpose: This paper focuses on the characterization of polymeric micelle-forming tuberculostatic prodrugs and the antimycobacterial activity of these prodrugs.Method: By the condensation of hydroxymethylpyrazinamide, ...
Preparation of polymeric micelles for use as carriers of tuberculostatic drugs
(Pharmacotherapy Group, 2007-12-01)
Purpose: This paper focuses on the characterization of polymeric micelle-forming tuberculostatic prodrugs and the antimycobacterial activity of these prodrugs.Method: By the condensation of hydroxymethylpyrazinamide, ...
Preformulation studies of novel 5′-O-carbonates of lamivudine with biological activity: solubility and stability assays
(Taylor & Francis, 2013-07)
As a part of preformulation studies, the aim of this work was to examine the solubility and stability of a series of 50 -O-carbonates of lamivudine with proven antihuman immunodeficiency virus activity. Solubility studies ...
Preparation of polymeric micelles for use as carriers of tuberculostatic drugs
(Pharmacotherapy Group, 2014)
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2014)
Synthesis and pharmaceutical properties of N-acyloxymethyl prodrugs of Allop with potential anti-trypanosomal activity
(Taylor, 2016-01)
We report herein the synthesis, and the physicochemical and pharmacokinetic properties of N-acyloxymethyl prodrugs of allopurinol (Allop) (2a-f). Allop is a compound with activity against Trypanosoma cruzi, a causative ...