Otros
The prodrug approach: A successful tool for improving drug solubility
Fecha
2016-01-01Registro en:
Molecules, v. 21, n. 1, 2016.
1420-3049
10.3390/molecules21010042
2-s2.0-85000542430
2-s2.0-85000542430.pdf
9734333607975413
0000-0003-4141-0455
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.