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Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000
(TAYLOR & FRANCIS INCPHILADELPHIA, 2012)
The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407). Consequently, the objective of this study was to evaluate ...
Unexpected Performance of Physical Mixtures over Solid Dispersions on the Dissolution Behavior of Benznidazole from Tablets
(Wiley, 2013-03)
This work investigated the feasibility of developing benznidazole (BZL) tablets, allowing fast, reproducible, and complete drug dissolution, by compressing BZL-Polyethylene Glycol (PEG) 6000 physical mixtures (PMs) and ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(2010-01-01)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol
(Elsevier B.V., 2021-02-15)
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms. Resveratrol solubility high-throughput ...
Development and physicochemical characterization of solid dispersions containing praziquantel for the treatment of schistosomiasis
(2017-02-01)
Praziquantel (PZQ) is an anthelminthic agent active against parasitic flatworms of the Schistosoma type and the most important drug for the treatment and morbidity control of schistosomiasis. In this study, a high-performance ...
Energy dispersive X-ray fluorescence spectrometric determination of lead after liquid-solid extraction with 1-(2-pyridylazo)-2-naphthol immobilized on silica.
(Soc Brasileira QuimicaSao PauloBrasil, 1996)
Development and Evaluation of Praziquantel Solid Dispersions in Sodium Starch Glycolate
(Pharmacotherapy GroupBenin CityNigéria, 2013)
Development and evaluation of praziquantel solid dispersions in sodium starch glycolate
(2013-04-01)
Purpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method ...
The Preparation of Ternary Solid Dispersions of an Herbal Drug via Spray Drying of Liquid Feed
(TAYLOR & FRANCIS INC, 2010)
The present study aimed the preparation and characterization of ternary solid dispersions by direct spray drying of a liquid suspension containing curcumin, a solubility enhancer and a drying aid. The experiments followed ...
Quercetin-PVP K25 solid dispersions: Preparation, thermal characterization and antioxidant activity
(Springer, 2011-04-01)
Quercetin is a flavonoid very well studied and has already entered clinical trials emerging as prospective anticancer drug candidate. In addition, quercetin has being reported to its free-radical scavenging activity and ...