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Polymeric Systems as Nanodevices for siRNA Delivery
(Bentham Science Publ Ltd, 2013-10-01)
The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this ...
Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90
(2017-01-01)
Hepatitis C (HCV) is a viral disease affecting millions of people worldwide, and persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma. During ...
Diethylaminoethyl- chitosan as an efficient carrier for siRNA delivery: Improving the condensation process and the nanoparticles properties
(2018-11-01)
Chitosan has been indicated as a promising carrier for the preparation of small interfering RNA (siRNA) delivery systems due to its remarkable properties. However, its weak interactions with siRNA molecules makes the ...
Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Mammalian cells have a large number of intracellular peptides that are generated by extralysosomal proteases. In this study, the enzymatic activity of thimet oligopeptidase (EP24.15) was inhibited in human embryonic kidney ...
Double-grafted chitosans as siRNA nanocarriers: effects of diisopropylethylamine substitution and labile-PEG coating
(Springer, 2022-03-31)
The preparation of safe and efficient siRNA carriers remains a challenge that has limited the therapeutic applications of siRNA. In this study, the design of a new small interfering RNA (siRNA) carrier based on ...
Strand Analysis, a free online program for the computational identification of the best RNA interference (RNAi) targets based on Gibbs free energy
(Sociedade Brasileira de Genética, 2007-01-01)
The RNA interference (RNAi) technique is a recent technology that uses double-stranded RNA molecules to promote potent and specific gene silencing. The application of this technique to molecular biology has increased ...
Desarrollo galénico de sistemas nanoparticulados innovadores para uso como vehículos de pequeños ARN de interferencia (siRNA)
(Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica, 2015)
Analysis of energetically biased transcripts of viruses and transposable elements
(Soc Brasil GeneticaRibeirao PretoBrazil, 2012)
Analysis of energetically biased transcripts of viruses and transposable elements
(SOC BRASIL GENETICARIBEIRAO PRETO, 2012)
RNA interference (RNAi) is a natural endogenous process by which double-stranded RNA molecules trigger potent and specific gene silencing in eukaryotic cells and is characterized by target RNA cleavage. In mammals, small ...
Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells
(Spandidos Publications, 2015)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...