A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole ...

Fragment-based molecular-replacement methods can solve a macromolecular structure quasi-ab initio. ARCIMBOLDO, using a common secondary-structure or tertiary-structure template or a library of folds, locates these with ...

Nanocellulose backbones highly regioselectively substituted with thiophene and long fatty acid side chains were synthesized via a protecting group strategy. The presence of long-chain pendants balanced the torsional ...

Guanylate cyclase-activating protein-2 (GCAP-2) is a retinal Ca2+ sensor protein. It plays a central role in shaping the photoreceptor light response and in light adaptation through the Ca2+-dependent regulation of the ...

Recently developed low fluorine containing polymers are advanced materials which confer advantageous properties to surfaces at a lower cost than conventional fluoropolymers (like PTFE), and are also more easily processable. ...

Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (CP, CR). The first step in catalysis, the reduction of peroxide substrate, is fast, 107 - 108 M−1s−1 ...

Cucurbitacins are secondary metabolites that mediate insect plant interactions not only as allomones against generalists but also as kairomones for specialist herbivores. This study was undertaken to identify the potential ...