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High bone mass from mutation of low-density lipoprotein receptor-related protein 6 (LRP6)
(Elsevier Science Inc., 2020-12)
Wnt/β-catenin signaling is important for skeletal development and health. Eleven heterozygous gain-of-function missense mutations within the first β-propeller of low-density lipoprotein receptor-related protein 5 (LRP5) ...
Markers of bone matebolism during 14 days of bed rest in young and older men
(ISMNI, 2017-01)
Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and toassess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwentbed ...
Nanostructured hydroxyapatite networks: Synergy of physical and chemical cues to induce an osteogenic fate in an additive-free medium
(Elsevier, 2018-05-26)
Nanoscale topography plays a central role in adult-stem-cell-niches. In this study we have demonstrated that by an accurate material design, mimicking the composition and structure of bone extracellular matrix, it is ...