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Héctor Terenzi, Armando Parodi, Enrique Rozengurt y colegas celebran el anuncio del Premio Nobel a Leloir
Investigadores del IIB Fundación Campomar celebrando el anuncio del Premio Nobel a Leloir. De izquierda a derecha: Héctor Terenzi, Armando J. Parodi, Enrique Rozengurt; 27 de octubre de 1970
Investigadores de la Fundación Campomar celebran el anuncio del Premio Nobel de Química a Leloir
Investigadores de la Fundación Campomar celebran el anuncio del Premio Nobel a Leloir. De izquierda a derecha: Carmen Sánchez, César Chelala, José M. Olavarría, Luis Jiménez de Asúa, Armando J. Parodi, Enrique Rozengurt. ...
Intracellular Ca2+ oscillations generated via the extracellular Ca2+-sensing receptor (CaSR) in response to extracellular Ca2+ or l-phenylalanine: Impact of the highly conservative mutation Ser170Thr
(Academic Press Inc Elsevier Science, 2015-11)
The extracellular Ca2+-sensing receptor (CaSR) is an allosteric protein that responds to changes in the extracellular concentration of Ca2+ ([Ca2+]e) and aromatic amino acids with the production of different patterns of ...
Metformin inhibition of colorectal cancer cell migration is associated with rebuilt adherens junctions and FAK downregulation
(Wiley, 2020-04-02)
E‐cadherin, a central component of the adherens junction (AJ), is a single‐pass trans- membrane protein that mediates cell?cell adhesion. The loss of E‐cadherin surface ex- pression, and therefore cell?cell adhesion, leads ...
Intracellular Ca2+ oscillations generated via the Ca2+-sensing receptor are mediated by negative feedback by PKCα at Thr888
(American Physiological Society, 2014-03)
To clarify the mechanism(s) underlying intracellular Ca2+ concentration ([Ca2+]i) oscillations induced by an elevation in extracellular Ca2+ concentration ([Ca2+]e) via the extracellular Ca2+-sensing receptor (CaR), we ...
Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells
(Pergamon-Elsevier Science Ltd, 2019-05-10)
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, ...
Protein kinase D1 inhibition interferes with mitosis progression
(Wiley-liss, Div John Wiley & Sons Inc, 2019-03-25)
Protein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, ...
Protein kinase D1 (PKD1) phosphorylation on Ser203 by type i p21-activated kinase (PAK) regulates PKD1 localization
(American Society for Biochemistry and Molecular Biology, 2017-06)
Although PKC-mediated phosphorylation of protein kinase D1 (PKD1) has been extensively characterized, little is known about PKD1 regulation by other upstream kinases. Here we report that stimulation of epithelial or ...