info:eu-repo/semantics/article
Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells
Fecha
2019-05-10Registro en:
Amable, Gastón Federico; Martínez León, Eduardo Antonio; Picco, María Elisa; Di Siervi, Nicolás; Davio, Carlos Alberto; et al.; Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells; Pergamon-Elsevier Science Ltd; International Journal of Biochemistry and Cellular Biology; 112; 10-5-2019; 88-94
1357-2725
CONICET Digital
CONICET
Autor
Amable, Gastón Federico
Martínez León, Eduardo Antonio
Picco, María Elisa
Di Siervi, Nicolás
Davio, Carlos Alberto
Rozengurt, Enrique
Rey, Osvaldo
Resumen
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, which plays a central role in intestinal homeostasis and sporadic colorectal cancer development, is regulated by phosphorylation cascades that are dependent and independent of Wnt. Here we report that a noncanonical Ser552 phosphorylation in β-catenin, which promotes its nuclear accumulation and transcriptional activity, is blocked by metformin via AMPK-mediated PI3K/Akt signaling inhibition.